In this book, the author presents a new vision of learning through design and production, and describes computer programming as a source of a learning and design power. As means of studying this extended notion of children's programming, the author implemented "Instructional Software Design Projects" to explore the learning that takes place when students develop complete mathematical software products designed for other students in their school. The results demonstrate that the young designers learned not only about mathematics (fractions) and programming (Logo), but also about design and user interfaces, as well as representational, pedagogical, and communicational issues.
This book describes in detail a unique and very precise operative technique that uses autologous cartilage/bone grafts for the reconstruction of load-bearing joint surfaces and for dowelling of non-unions. The technique, employing diamond instruments and a wet grinding process, has been developed and refined over the past 30 years at the Center for Orthopaedic Sciences (ZOW), first in Bern and later in Munich. A step-by-step description of the method is provided for each indication, with the aid of many high-quality illustrations. Correctly applied, the technique has been very successful in restoring high-level athletes to competition; it can be applied even in "hopeless cases" and offers excellent late results. This guide will be invaluable for orthopaedic surgeons wishing to master this proven and effective approach.
Helps you choose the right computational tools and techniques to meet your drug design goals <p> <i>Computational Drug Design</i> covers all of the major computational drug design techniques in use today, focusing on the process that pharmaceutical chemists employ to design a new drug molecule. The discussions of which computational tools to use and when and how to use them are all based on typical pharmaceutical industry drug design processes. <p> Following an introduction, the book is divided into three parts: <ul> <li> <p> Part One, The Drug Design Process, sets forth a variety of design processes suitable for a number of different drug development scenarios and drug targets. The author demonstrates how computational techniques are typically used during the design process, helping readers choose the best computational tools to meet their goals. <li> <p> Part Two, Computational Tools and Techniques, offers a series of chapters, each one dedicated to a single computational technique. Readers discover the strengths and weaknesses of each technique. Moreover, the book tabulates comparative accuracy studies, giving readers an unbiased comparison of all the available techniques. <li> <p> Part Three, Related Topics, addresses new, emerging, and complementary technologies, including bioinformatics, simulations at the cellular and organ level, synthesis route prediction, proteomics, and prodrug approaches. </ul> <p> The book's accompanying CD-ROM, a special feature, offers graphics of the molecular structures and dynamic reactions discussed in the book as well as demos from computational drug design software companies. <p> <i>Computational Drug Design</i> is ideal for both students and professionals in drug design, helping them choose and take full advantage of the best computational tools available. <p> <b>Note:</b> CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
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